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Detail from "Konig Karl II von Spanien" (Son of
Phillip IV, King of Spain), c. 1652 by Diego Rodriguez
de Silva y Velazquez (1599-1660) - Kunshistorishes Museum, Vienna, Austria.
Note the overgrowth of the mid facial structures,
particularly the jaw or lower mandible and nose due to
the effects of an inherited familial autosomal dominant gene.
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